What are the best weapons to use in Resident Evil 4?

In Resident Evil 4 Gold Edition, the best weapons balance power, reliability, and upgrade potential. The Riot Gun is the premier crowd-control tool in close- to mid-range engagements. The Red9 is widely regarded as the strongest handgun you’ll rely on through most of the game, and the Handcannon remains the ultimate late-game option for boss encounters thanks to its high damage and, in some modes, unlimited ammunition. For long-range threats, the Stingray is a top choice among rifles, while the SR M1903 offers extreme single-shot power for tougher targets. Round out your kit with the Blacktail as a versatile sidearm, the Punisher for precise crowd-control, and the LE 5 as a capable, fast-firing SMG. If you own the Extra DLC Pack, you can further amplify your firepower with the Sentinel Nine and Skull Shaker, which are fully functional in the main story. TheGamer on Riot Gun and Handcannon • CBR on Red9 and other handguns • GameRant on high-power rifles/sniper options

Loadout examples and how they fit into playstyles: - Riot Gun: best for mowing down mobs and controlling space in tight corridors. - Red9: your reliable all-round handgun with strong power and upgrade potential. - Handcannon: end-game boss killer with high damage and, in some modes, infinite ammo. - Stingray / SR M1903: pick Stingray for steady mid-range fire or SR M1903 for one-shot power at distance. - Blacktail and Punisher: solid secondary pistols to cover scenarios where ammo is tight or rapid shots are needed. - LE 5: strongest automatic option among the SMGs you’ll carry. - Deluxe weapons: Sentinel Nine and Skull Shaker can be claimed from the Extra DLC Pack and used in the main story, offering extra firepower. ProGameTalk on LE 5 and other weapons • Steam pages confirming Sentinel Nine and Skull Shaker • Steam page for Skull Shaker

Note: Always ensure you’re on the latest patch before playing Separate Ways or using the Extra DLC Pack, as recommended in the Gold Edition release notes. This helps ensure all weapons, and Deluxe content, function correctly with Ada Wong’s scenario and other additions.